Comparing the Liver According to Traditional Chinese and Western Scientific Physiology

Perhaps in no organ system is the similarity and difference between Western physiological and Traditional Chinese physiology more
evident than in the TCM description of the liver. The difference is essentially that of form and function but since the liver's known
Western physiological functions are so complex, it is possible for the Western scientific mind to clearly see the bridge between body
and mind that is at the heart of TCM theory.

To come to a full appreciation of the depth of observation and knowledge that over 5000 years of Chinese medical theory achieved
can only serve to amplify the remarkable scientific edifice that has been created in the last 150 years or so in Western medical
physiology. The two can only serve to help each other as a kind of check and balance. It would be a tragedy of profound ignorance if
the West turned its back on the profound physiological wisdom of the ancient medical systems simply because of impatience in
dealing with its cultural jargon and other semantic difficulties.

Finally, it is no accident that the ancient Chinese assigned the liver and gall bladder to the wood element. Probably no other organ
system is so keyed to respond to botanical medicine as is the liver. Most people around the word recognize as part of their folk
heritage the importance of vegetables to a healthy liver. Further, it is the bitter flavor of certain herbs that specifically triggers the
secretion of bile that aids digestion as well as liver metabolism generally.

The first TCM description might actually serve as a summary to a description of all other liver functions. It is, however, the essential
way that most TCM practitioners access and remember the various complex functions of the liver in clinical settings.

The liver is the general governing the body mind:

While the heart is the king or supreme commander over all body-mind functions, the Chinese describe the liver as the general or
long-range planner. Let's consider what this actually means in terms of Western Physiology:

First consider how a good general helps defend against external invasions and attacks and how the liver similarly protect the
body-mind from various external poisons and pathogens. In this regard, the liver serves as an important citadel for the function of the
immune system as it is primarily responsible for detoxification and elimination of various metabolic poisons. While the external
immune system is involved in overcoming pathological bacteria and viruses throughout the body, the liver make the process more
efficient by removing the debris in the form of vanquished and exhausted blood cells and other metabolic wastes from the blood. In
this way renewed cells can arise within the blood to continue the process of phago-cytosis and other protective functions.

The liver serves as long-range planner by refining, filtering, using and storing important nutrients such proteins, glycogen, vitamins
and various minerals including iron for immediate and future use. The planning capacity of the liver is also demonstrated by its ability
to chemically alter or excrete different hormones including thyroxin and essentially all the steroid hormones such as estrogen,
cortisol, aldosterone and so forth. While many of these are generated as part of natural physical cycles, they can also be radically
thrown out of balance in reaction to fear or stress and thus the liver plays a key role in helping to maintain a clear and balanced
mental state.
The liver is also actively involved in detoxifying and excreting into the bile many different drugs, including
sulfonamides, penicillin, ampicillin and erythromycin to name a few.

The liver regulates the smooth flowing of chi

Glucose is stored in the body in the form of glycogen. While all cells are capable of storing some glycogen, liver cells are uniquely
able to store up to 5 to 8 per cent of their weight as glycogen. One of the important functions of the liver is to re transform glycogen
into glucose and release it into the blood as needed to maintain a relatively constant energetic balance.
Impaired liver function
can cause fatigue, irritability and depression
as a result of impaired glycogenesis which is the breakdown of glycogen to re-form
glucose in the cells.

The liver harmonizes digestion

The process of gluconeogenesis described previously demonstrates the liver's ability to play a key role in the digestion and
metabolism of carbohydrates. Faulty carbohydrate metabolism by the liver will cause blood glucose to radically rise or fall causing
either hypo or hyperglycemia.

The liver is also of primary importance in fat metabolism. There are four primary liver functions involved with fat metabolism: 1. The
release of energy from the breakdown and burning of fatty acids and the formation of acetic acid, 2. The formation of lipoproteins, 3.
The formation of cholesterol and phospholipids that are found in cell membranes and intracellular structures throughout the body 4.
The conversion of large quantities of carbohydrates to fat.

Besides these, the secretion of bile salts into the duodenum neutralizes the acidified food material that has passed from the stomach.
Bile also stimulates natural intestinal peristalsis that helps regulate bowel movement.

The liver harmonizes the emotions

The fact those large amounts of liver tissue must be adversely affected in order to show up as liver dysfunction in customary liver
tests. Before these are obvious given the present imprecision of these physical tests, abnormalities of liver function are readily
diagnosed according to abnormal emotional reactions.

The correlation of mood swings is clearly recognized and attributed as a result of rising and falling blood sugar levels. However, the
liver's inability to maintain appropriate levels of alkalinity as food passes from the stomach to the duodenum can result in dyspeptic
symptoms ranging from relatively mild abdominal pains to severe ulcers. This complex can be related to what in TCM is termed as
liver invading spleen or irregular or stagnant liver chi.

Further, the liver's function of excreting different hormones associated with stress and cyclical imbalance may be impaired as a result
of its having to contend with other important functions such as the detoxification of drugs and various external pollutants.
re-circulation of various stress related hormones will result in radical mood shifts and inappropriate angry behavior.

Through this process we see that the liver is responsible for the detoxification and elimination of both endogenous as well as
exogenous toxins. Endogenous toxins are produced from various stresses and attitudes while exogenous toxins are the result of
external toxins and pollutants from air, food and water.

While both types of toxins are often present, endogenous, thought-produced toxins can result in extreme feelings of anger and
frustration, hypertension, hyperthyroidism, premenstrual tension, aggravation of menopausal symptoms and other physiological and
behavioral symptoms.

All of these obviously play upon the nervous system and it is a fundamentally important aspect of herbal strategy to treat various
psychological and neurological symptoms by using herbal cholagogues that aid the secretion of bile and thereby help clear the liver.

Irregular liver chi causing cysts, tumors and breast lumps

Blockage of liver chi also causes swelling of the glands in various parts of the body and in women predisposes them to the formation
of cysts and lumps in the reproductive organs and tumors and lumps in the breast. These are specifically caused by an accumulation
of toxins, which the liver is unable to process and eliminate.

One Chinese herb that is commonly used in the West for treating liver conditions is dandelion. Chinese medicine specifically uses the
entire plant of the dandelion, the upper part as well as the root for clearing heat and detoxifying fire poison as well as reducing
abscesses, dissipating nodules, treating all problems of the breast. This includes breast lumps and tumors.

In Western medicine dandelion can also be used and one can also consider the use of dried pokeroot, since it is considered
specifically effective for treating all glandular diseases.

Liver Stores the blood

Rather than pass directly to the cells of the body, all nutrients absorbed from the intestinal walls are channeled into a special vein
called the "portal vein". While all other veins go directly to the heart from where they are pumped and distributed throughout the
body, the portal vein goes into the liver where it opens into a bed of fine capillaries. This food enriched blood is circulated around
and through the liver cells where it is further processed then either immediately used or stored for future need. Eventually the
nutrient enriched blood is collected into another large vein called the "vena cava" where it finally empties into the heart for general
distribution throughout the body.

An increase in veinous pressure that drains and circulates through the liver can cause the liver to markedly swell. The liver can store
from 200 to 400 ml. of blood as a result of only relatively slight rise (4 to 8 mm. Hg) in hepatic venous pressure. For this reason, if
none other, the liver is one of the major blood reservoirs. Further, during a pathological hemorrhage condition where large amounts
of blood are lost, much of the normal blood stored in the liver sinusoids is drained into the remainder of the circulation to replace the
lost blood.

Another concept involving the liver's ability to store blood is the regulation of clotting functions. The liver does this by producing
many of the plasma clotting factors including prothrombin and fibrinogen as well as the production of bile salts necessary for the
absorption of vitamin K which is needed for the production of the various clotting factors.

Liver opens to the eyes

Beta-Carotene is converted to the retinal form of vitamin A in the liver. Vitamin A then combines with a protein opsin to form
rhodopsin (visual purple). Rhodopsin is found in the rod cells of the retina and is responsible for night vision. Light striking the retina
splits the rhodopsin molecule that generates an electrical impulse that sends information to the brain. Each time rhodopsin is split, a
small amount of retinal is destroyed. Night vision is impaired when there is a lack of re synthesis of retinal necessary for forming
visual purple. In addition, other light sensitive pigments require the presence of vitamin A. These include iodopsin, cyanopsin and
porphyropsin, all of which are color pigments in cone cells of the retina.

One other way that the liver governs the eyes is the maintenance of epithelial tissue. This tissue is particularly important for the
proper function of the cornea as well as all other mucus secreting membranes of the body, including the gastrointestinal tract, the
lungs, the vagina, the urinary tract, the bladder and the skin. Dryness of these organs is diagnosed in Chinese medicine as liver yin
deficiency. This suggests that various yin tonics such as rehmannia, lycii berries, asparagus root and ophiopogon play a significant
role in supply substantial amounts of beta carotene as the precursor of vitamin A and/or somehow nurturing the mucus secreting
epithelial tissues of the body.

A lack of vitamin A will also cause keratitis which is an ulcerous inflammation and hardening of the cornea as well as other associated
parts of the eye such as the conjunctiva. Vitamin A deficiency due to either a lack of nutritional sources of vitamin A or its precursor
in the form of beta-carotene or the function of transforming beta-carotene into vitamin A in the liver manifests with symptoms such as
dryness of the eye, inflammatory eye diseases, excessive lacrimation, pain, photophobia, impaired night vision and
general vision loss.

The liver opens to the nails of the hands and feet

The nail consists of a particular hard, horny tissue composed largely of keratin. Keratin is an extremely tough protein material that
comprises the bulk of hair, nails and horny tissue. It is generally insoluble in water, weak acids or alkalis and unaffected by most
proteolytic enzymes. The fibrous protein is produced by keratinocytes found in the body in two forms, hard and soft.

It grows from a root in the nail-bed or matrix at the tips of the fingers and toes. This consists of epithelium and cornium continuous
with the epidermis and dermis of the skin of the nail fold. The white crescent shaped moons located near the root is called the lunula.

The nail grows in length and thickness through the activity of cells in the stratum germinativum of the nail root. The average nail
growth rate is 1 mm per week. The complete nail replaces itself on the average every 4 to 6 months. Nail growth varies with age and
certain diseases and hormonal imbalances.

Differential diagnosis of the nails is determined by various indications many of which are indirectly related to primary liver functions
relating to protein metabolism, the production of hemoglobin, the liver's synthesis of vitamin A from beta-carotene and the presence
of certain toxic metabolites such as arsenic, mercury, silver and other toxic substances which the liver is unable to fully discharge and
have clinically verifiable indications that can show up on the nails. In general, a thickening or weakening of the nails is directly related
to the metabolism of Vitamin A.

Some of the abnormal indications that are diagnosed upon examination of the nails are as follows:

Nail ridges may occur as a sign of defective nutrition or after a serious illness.

In the absence of hydrochloric acid (achlorydia) or anemia caused by a decrease of blood cells (hypochromia), the nails may be
excessively spoon shaped and depressed in the center.

Chronic pulmonary conditions and congenital heart disease can result in spongy excess of soft tissue at the base of the nails and
may be associated with clubbed fingers.

Atrophy of the nails may occur as a result of congenital defects. In Traditional Chinese Medicine (TCM), besides indicating the
condition of the liver, this also be considered a problem of the "yuan chi" or congenital energy associated with kidney chi, involving
the endocrine glands.

Nail shedding or permanent atrophy of the nails can follow injuries, scars, frostbite, nerve injuries and hyperthyroidism.

Prolonged contact with chemicals as well as too frequent manicuring can cause nails to become fragile or split easily.

Various other diseases such as injury to the nerve or finger, neuritis, raynaud's disease, pulmonary osteoarthropathy, syphilis,
onychia, scleroderma, acrodermatitis and granuloma fungoides of the fingers can result in dry, malformed nails.

Transverse lines (Beau's lines) can result from earlier interference with nail matrix growth. This can result from local or systemic
imbalances and can be approximately dated according to the placement of the line or lines on the nail.

Nail discolorations: Black indicates gangrene perhaps caused by diabetes. Blue-black is due to stagnant blood under the nail and
can be a sign of hemophilia and trauma. This can be painful and is treated by drilling a small hole in the nail at the site of the
hemorrhage. Brown is a possible sign of arsenic poisoning. Brownish-black may indicate chronic mercurial poisoning caused by the
formation of sulfide of mercury in the tissues. Cyanosis usually indicates anemia, poor circulation or venous stasis. White spots may
be caused by trauma and are usually found in women. Transverse white bands in all nails may be a sign of acute or chronic arsenic

Considering that many of the above indications represent some toxic reaction in the body, and that the liver is the organ that
primarily deals with detoxification of the blood as well as the overall health of the blood, the TCM concept that the "nails are the
flowering of the liver" is quite understandable in terms of present scientific physiology.

Liver Wind

The essential expression of the liver is appropriate tension. This is expressed in various functions especially the restrained process
of bile secretion from the liver through the gall bladder to the small intestine. The bile itself then acts as a natural irritant to the lining
of the intestine that stimulates appropriate peristalsis that promotes the movement of feces through the lower intestine.

As a result of this process, the liver is described as ruling the nervous system. "Wind" in Chinese medicine describes a concept
appropriate to any internal or external physiological movement. Spreading infectious diseases from the common cold, flu or skin rash
is described as wind as is rheumatic and arthritic symptoms. Headaches, stroke or chorea are described as internal wind because
they are primarily caused by an imbalance of the internal organs.

A number of liver herbs with antispasmodic properties are very effective for relieving symptoms of liver wind. Two Chinese herbs in
particular are gambir (uncaria rhyncholphylla) (gou teng) and gastrodia (gastrodiae elatae) (tian ma). Both of these are powerful
antispasmodic herbs that release symptoms of liver wind including tremors, seizures and symptoms such as headaches, dizziness,
and chorea. They are also useful in relieving rheumatic pains.